Fioricet (Butalbital, Acetaminophen, and Caffeine Tablets, USP) is supplied in tablet form for oral administration.
Butalbital (5-allyl-5-isobutylbarbituric acid) is a short- to intermediate-acting barbiturate. It has the following structural formula:
Acetaminophen (4´-hydroxyacetanilide) is a non-opiate, non-salicylate analgesic and antipyretic. It has the following structural formula:
Butalbital is well absorbed from the gastrointestinal tract and is expected to distribute to most tissues in the body. Barbiturates in general may appear in breast milk and readily cross the placental barrier. They are bound to plasma and tissue proteins to a varying degree and binding increases directly as a function of lipid solubility.
Elimination of butalbital is primarily via the kidney (59% to 88% of the dose) as unchanged drug or metabolites. The plasma half-life is about 35 hours. Urinary excretion products include parent drug (about 3.6% of the dose), 5-isobutyl-5-(2,3-dihydroxypropyl) barbituric acid (about 24% of the dose), 5-allyl-5(3-hydroxy-2-methyl-1-propyl) barbituric acid (about 4.8% of the dose), products with the barbituric acid ring hydrolyzed with excretion of urea (about 14% of the dose), as well as unidentified materials. Of the material excreted in the urine, 32% is conjugated.
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Fioricet is a medication used to treat migraine and tension headaches. It is a combination of acetaminophen, butalbital, and caffeine. Acetaminophen is a pain reliever and fever reducer.
Butalbital is in a group of drugs called barbiturates. It relaxes muscle contractions involved in a tension headache.
Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.
Fioricet is used to treat tension headaches that are caused by muscle contractions.
Fioricet may also be used for other purposes not listed in this medication guide.
Do not use Fioricet if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take Fioricet before the MAO inhibitor has cleared from your body.
Do not take more Fioricet than is recommended. An overdose of acetaminophen can cause damage to your liver. Do not use any other cold, allergy, pain, or sleep medication without first asking your doctor or pharmacist. Acetaminophen (sometimes abbreviated as "APAP") is contained in many combination medicines. If you use certain products together with Fioricet you may accidentally use too much acetaminophen. Read the label of any other medicine you are using to see if it contains acetaminophen or APAP. Avoid drinking alcohol. It can increase the risk of liver damage while you are taking acetaminophen. If you drink more than three alcoholic beverages per day, do not take acetaminophen without your doctor's advice, and never take more than 2 grams (2000 mg) per day.
According to the staff at the renowned Mayo Clinic, a number of things are identified triggers for migraines.
As you learn to recognize your own unique migraine triggers, it can be helpful to know the list of the following triggers as they have been recognized as common by medical staff and health care providers.
In addition foods such as chocolate, nuts, peanut butter, avocado, banana, citrus, onions, dairy producs and pickled foods are commonly known to be migraine triggers foods. It is important to know this fact triggers do not always cause migraine to start, so avoiding triggers not always prevent your migraines. Identifying and avoiding triggers can only take your part of the way to preventing migraines.
Most Migraine Symptoms last a minimum of 4 hours,
but some can last for months.
Usually on one side of the head, in the temples or behind one eye or ear. The pain can be debilitating.
Zig-zag or static patterns are just some of the visual disturbances that occur. 80% of migraine sufferes are sensitive to light.
76% are extremely sensitive to sound.
40 - 50% experience a change in their sence of smell often reporting perfumes, food and cigarette smoke to be most offensive.
73% experience nausea and /or vomiting during an attack.
Tingling and numbness is often reported. Weakness is limb and lack of control are some time reported during attack.